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<i>Fissistigma poilanei<_i> (Ast) Tsiang et P. T. Li

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By Targets:	Apoptosis (2) Bacterial (1) Bcr-Abl (1) c-Kit (1) Cholinesterase (ChE) (1) Drug Metabolite (2) EGFR (6) Endogenous Metabolite (2) FLT3 (1) Galectin (1) Glutaminase (1) Phosphodiesterase (PDE) (1) Proteasome (1) RET (1) Toll-like Receptor (TLR) (2) TRP Channel (1) VEGFR (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (2)
Oligonucleotides:	Antisense Oligonucleotides (2)

Inhibitors & Agonists

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Natural
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Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138627A

AST5902 trimesylate	EGFR Drug Metabolite	Cancer
AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. AST5902 trimesylate exerts antineoplastic activity. Alflutinib is an EGFR inhibitor .

HY-15002

AST 487 4 Publications Verification NVP-Ast 487	RET FLT3 VEGFR c-Kit Bcr-Abl	Cancer
AST 487 is a RET kinase inhibitor with IC₅₀ of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC₅₀ of 520 nM.

HY-13427

Allitinib tosylate 1 Publications Verification Ast-1306 (TsOH)	EGFR	Cancer
Allitinib tosylate (AST-1306 (TsOH)) is an orally active and irreversible EGFR and ErbB2 inhibitor with IC₅₀s of 0.5 and 3 nM, respectively. Allitinib tosylate also inhibits ErbB4 with an IC₅₀ of 0.8 nM. Allitinib tosylate is an anilino-quinazoline compound and has anti-cancer activity

HY-15375

Allitinib 1 Publications Verification Ast-1306; ALS 1306	EGFR	Cancer
Allitinib (AST-1306) is an orally active and irreversible EGFR and ErbB2 inhibitor with IC₅₀s of 0.5 and 3 nM, respectively. Allitinib also inhibits ErbB4 with an IC₅₀ of 0.8 nM. Allitinib is an anilino-quinazoline compound and has anti-cancer activity .

HY-N9356

Oxocrebanine	Others	Others
Oxocrebanine, an aporphine alkaloid, can be found in Fissistigma poilanei (Annonaceae) .

HY-153812

AST 7062601 Ast070	Others	Metabolic Disease
AST 7062601 (AST070) is a Ucp1 inducer that strongly induces endogenous Ucp1 expression in primary mouse brown adipocytes. Ucp1 refers to uncoupling protein, found in brown and beige fat cells. In mammals, UCP1 oxidizes fatty acids and uncouples ATP production in mitochondria to promote energy dissipation as heat. AST 7062601 can be used to study thermogenic, uncoupled respiration .

HY-138627

AST5902	Drug Metabolite EGFR	Cancer
AST5902 is the active metabolite of Firmonertinib (HY-112870) (EGFR inhibitor). AST5902 has antineoplastic activity .

HY-138627B

AST5902 mesylate	Others	Cancer
AST5902 mesylate is a principal metabolite of Alflutinib, exhibiting significant antineoplastic activity. AST5902 mesylate contributes to the overall pharmacological effects in the treatment of non-small cell lung cancer. AST5902 mesylate is involved in the response to activating EGFR mutations and can help overcome EGFR T790M drug-resistant mutations.

HY-N9379

Fissistigine A	Others	Others
Fissistigine A is an alkaloid separated of the basic fractions from Formosan Fissistigma glaucescens, F. oldhamii and Goniothalamus amuyon .

HY-147780

Fissitungfine B	Others	Cancer
Fissitungfine B is a compound extracted from the tropical medicinal plant Fissistigma tungfangense. Fissitungfine B has strong anticancer activity .

HY-158378

Trivalent hydroxyarsinothricn R-Ast-OH	Glutaminase	Cancer
Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible kidney-type glutaminase (KGA) inhibitor. Trivalent hydroxyarsinothricn binds to the glutamine binding site and forms a covalent bond with an active site cysteine residue. Trivalent hydroxyarsinothricn selectively kills triple-negative breast cancer (TNBC) cells and is not cytotoxic to the control cell line. KGA is the enzyme that controls glutamine metabolism and is correlated with tumor malignancy .

HY-N4033

Horminone 7α-Hydroxyroyleanone	Bacterial	Infection
Horminone is an abietan diterpene quinone that can be isolated from Labiatae family. Horminone increases of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum levels in vivo. Horminone inhibits the growth of Trypanosoma cruzi and shows antibacterial activity .

HY-N6595

Lucidone A	Others	Others
Lucidone A is a lanostanoid isolated from the fruiting bodies of G. resinaceum. lucidone A showed inhibitory effects against the increase of ALT and AST levels in HepG2 cells induced by H2O2 compared to a control group in the range of their maximum non-toxic concentration (MNTC) .

HY-P3016

Aspartate aminotransferase, Genetically engineered bacteria EC 2.6.1.1; GOT; Ast	Endogenous Metabolite	Others
Aspartate aminotransferase, Genetically engineered bacteria (EC 2.6.1.1) (AST) is a transaminase enzyme, is often used in biochemical studies. Aspartate aminotransferase catalyzes aspartate and alpha-ketoglutarate converts to oxaloacetate and glutamate. Aspartate aminotransferase can be found in cerebrospinal fluid, exudates, and transudates .

HY-W012092

Ethyl 3,4,5-trimethoxybenzoate	Others	Others
Ethyl 3,4,5-trimethoxybenzoate is a natural compound isolated from the roots of Rauvolfia yunnanensis Tsiang .

HY-N8643

Dihydropedicin	Others	Others
Dihydropedicin is a Chalcones product that can be isolated from the herbs of Fissistigma lanuginosum .

HY-N3099

Pedicin	Others	Others
Pedicin is a Chalcones product that can be isolated from the herbs of Fissistigma oldhamii .

HY-139785

Cavrotolimod Ast-008	Toll-like Receptor (TLR)	Others Cancer
Cavrotolimod is an immunostimulatory spherical nucleic acid (SNA) modified with type B CpG oligonucleotides designed to agonize TLR9 and elicit immune responses useful in oncology applications.

HY-139785A

Cavrotolimod sodium Ast-008 sodium	Toll-like Receptor (TLR)	Others
Cavrotolimod sodium is an immunostimulatory spherical nucleic acid (SNA) modified with type B CpG oligonucleotides designed to agonize TLR9 and elicit immune responses useful in oncology applications.

HY-N1730

2-Hydroxy-3,4,5,6-tetramethoxychalcone	Others	Others
2-Hydroxy-3,4,5,6-tetramethoxychalcone is a Chalcones product that can be isolated from the herbs of Fissistigma bracteolatum .

HY-133528

OptoBI-1	TRP Channel	Neurological Disease
OptoBI-1 is a photochromic TRPC3 agonist, which asts as a photopharmacological tool to control of neuronal firing .

HY-112870A

Firmonertinib mesylate 3 Publications Verification Alflutinib mesylate; Furmonertinib mesylate; Ast2818 mesylate	EGFR	Cancer
Firmonertinib (Alflutinib; Furmonertinib) mesylate is is an orally active, mutant-selective, and highly brain penetrant EGFR inhibitor. Firmonertinib mesylate inhibits EGFR active mutations as well as the T790M acquired resistant mutation. Firmonertinib mesylate has the potential for the research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation .

HY-112870

Firmonertinib 3 Publications Verification Alflutinib; Furmonertinib; Ast2818	EGFR	Cancer
Firmonertinib (Alflutinib; Furmonertinib) is an orally active, mutant-selective, and highly brain penetrant EGFR inhibitor. Firmonertinib inhibits EGFR active mutations as well as the T790M acquired resistant mutation. Firmonertinib has the potential for the research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation .

HY-N12027

AChE/BChE-IN-14	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-14 (compound 13) is a benzylisoquinoline alkaloid isolated from the roots of Fissistigma polyanthum. AChE/BChE-IN-14 exhibits AChE and BChE inhibitions with antioxidant activities. AChE/BChE-IN-14 can be used for Alzheimer’s disease research .

HY-P3690

Ac-Leu-Leu-Norleucinol	Proteasome	Others
Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST) .

HY-162583

PDE4-IN-17	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE4-IN-17 (compound 4e) is a potent PDE4 inhibitor. PDE4-IN-17 inhibits PDE4B and PDE4D with IC₅₀s of 10.0 and 15.2 nM, respectively. PDE4-IN-17 has good oral bioavailability (F=66%) and longer half-life (t_1/2=2.0 h) in SD rats .

HY-P3016B

Aspartate aminotransferase, Human liver GOT, Human liver; Ast, Human liver	Endogenous Metabolite	Metabolic Disease
Aspartate aminotransferase (GOT), Human liver is an aminotransferase derived from human liver and is commonly used in biochemical research. Aspartate aminotransferase, Human liver catalyzes the conversion of aspartate and alpha-ketoglutarate to oxaloacetate and glutamate .

HY-N2638

Ilexsaponin A	Apoptosis	Cardiovascular Disease
Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes .

HY-N2638R

Ilexsaponin A (Standard)	Apoptosis	Cardiovascular Disease
Ilexsaponin A (Standard) is the analytical standard of Ilexsaponin A. This product is intended for research and analytical applications. Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes .

HY-147041

Selvigaltin GB1211	Galectin	Inflammation/Immunology Cancer
Selvigaltin (GB1211) is an orally active galectin-3 small molecule inhibitor with an IC₅₀ value of 12 nM in rabbits, showing anti-tumor activity. Selvigaltin decreases galectin-3 levels in the liver and reduces biomarkers of liver function (AST, ALT, bilirubin), inflammation (cells foci) and fibrosis (PSR, SHG), as well as decreasing the mRNA and protein expression of several key inflammation and fibrosis biomarkers (IL6, TGFβ3, SNAI2, collagen). Selvigaltin restores T-cell activity and induces less tumors and metastasis .

Cat. No.	Product Name	Target	Research Area

HY-P3690

Ac-Leu-Leu-Norleucinol	Proteasome	Others
Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST) .

Ethyl 3,4,5-trimethoxybenzoate	Apocynaceae Rauvolfia verticillata (Lour.) Baill. Natural Products Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Others
Ethyl 3,4,5-trimethoxybenzoate is a natural compound isolated from the roots of Rauvolfia yunnanensis Tsiang .

Ilexsaponin A	Cardiovascular Disease Aquifoliaceae Triterpenes Classification of Application Fields Terpenoids Source classification Ilex pubescens Hook. et Arn. Plants Disease Research Fields	Apoptosis
Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes .

Oxocrebanine	Alkaloids Classification of Application Fields Source classification Other Diseases Plants Annonaceae Isoquinoline Alkaloids Disease Research Fields Fissistigma poilanei (Ast) Tsiang et P. T. Li	Others
Oxocrebanine, an aporphine alkaloid, can be found in Fissistigma poilanei (Annonaceae) .

Fissistigine A	Alkaloids Monophenols Classification of Application Fields Goniothalamus amuyon (Bl.) Merr. Source classification Other Diseases Phenols Plants Annonaceae Isoquinoline Alkaloids Disease Research Fields	Others
Fissistigine A is an alkaloid separated of the basic fractions from Formosan Fissistigma glaucescens, F. oldhamii and Goniothalamus amuyon .

Horminone 7α-Hydroxyroyleanone	Quinones Structural Classification Verbenaceae Source classification Verbena officinalis Linn. Plants Phenanthrenequinones	Bacterial
Horminone is an abietan diterpene quinone that can be isolated from Labiatae family. Horminone increases of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum levels in vivo. Horminone inhibits the growth of Trypanosoma cruzi and shows antibacterial activity .

Lucidone A	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Others
Lucidone A is a lanostanoid isolated from the fruiting bodies of G. resinaceum. lucidone A showed inhibitory effects against the increase of ALT and AST levels in HepG2 cells induced by H2O2 compared to a control group in the range of their maximum non-toxic concentration (MNTC) .

Dihydropedicin	Structural Classification Chalcones Flavonoids Source classification Plants Annonaceae Fissistigma lanuginosum (Hook.f. & Thomson) Merr.	Others
Dihydropedicin is a Chalcones product that can be isolated from the herbs of Fissistigma lanuginosum .

Pedicin	Structural Classification Chalcones Flavonoids Source classification Plants Annonaceae Fissistigma oldhamii (Hemsl.) Merr.	Others
Pedicin is a Chalcones product that can be isolated from the herbs of Fissistigma oldhamii .

2-Hydroxy-3,4,5,6-tetramethoxychalcone	Structural Classification Chalcones Flavonoids Ketones, Aldehydes, Acids Source classification Plants Annonaceae Fissistigma bracteolatum Chatterjee	Others
2-Hydroxy-3,4,5,6-tetramethoxychalcone is a Chalcones product that can be isolated from the herbs of Fissistigma bracteolatum .

AChE/BChE-IN-14	Structural Classification Alkaloids Fissistigma polyanthum (Hook. f. et Thoms.) Merr. Source classification Plants Annonaceae Isoquinoline Alkaloids	Cholinesterase (ChE)
AChE/BChE-IN-14 (compound 13) is a benzylisoquinoline alkaloid isolated from the roots of Fissistigma polyanthum. AChE/BChE-IN-14 exhibits AChE and BChE inhibitions with antioxidant activities. AChE/BChE-IN-14 can be used for Alzheimer’s disease research .

Ilexsaponin A (Standard)	Aquifoliaceae Triterpenes Structural Classification Terpenoids Source classification Ilex pubescens Hook. et Arn. Plants	Apoptosis
Ilexsaponin A (Standard) is the analytical standard of Ilexsaponin A. This product is intended for research and analytical applications. Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes .

Cat. No.	Compare	Product Name	Species	Source

HY-P703316

	SLC17A5 Protein, Human (HEK293, His, MBP, Flag) Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; Ast; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT; SLC17A5; Homo sapiens; Human; Ast	Human	HEK293
	SLC17A5 Protein, Human (HEK293, His, MBP, Flag) is the recombinant human-derived SLC17A5, expressed by HEK293 , with His, MBP, Flag labeled tag. ,

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Cat. No.	Product Name		Classification

HY-139785

Cavrotolimod Ast-008		Antisense Oligonucleotides
Cavrotolimod is an immunostimulatory spherical nucleic acid (SNA) modified with type B CpG oligonucleotides designed to agonize TLR9 and elicit immune responses useful in oncology applications.

HY-139785A

Cavrotolimod sodium Ast-008 sodium		Antisense Oligonucleotides
Cavrotolimod sodium is an immunostimulatory spherical nucleic acid (SNA) modified with type B CpG oligonucleotides designed to agonize TLR9 and elicit immune responses useful in oncology applications.

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<i>Fissistigma poilanei<_i> (Ast) Tsiang et P. T. Li

Inhibitors & Agonists

Peptides

NaturalProducts

Recombinant Proteins

Oligonucleotides

Natural
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